ABSTRACT
Serum concentrations Of sialic acid(SA), fucose (Fuc) , ?1-acid glycoprotein (?1-AG), haptoglobi (HP),?1-antitrypsin (?1-AT), Prealbumin (PA) and tranrf-errin (TF)were co comitantly measured in 31 patier's with AFP negative primary hepatocellular carcinoma (HCC) , 33 with AFP positive HCC, 35 with cirrhosis and 58 normal blood donors. The results revealed that serum SA, Fuc, ?1-AG, HP and ?1-AT levels were all significantly higher in patients with AFP negative HCC than in control groups. Among them, Fuc, ?1-AG and HP levels were significantly higher in patients with AFP negative HCC than in AFP positive HCC. Therefore, measurements of these five indices are suggested in the diagnosis of the AFP negative HCC.Furtheremore, the raised concentration of protein bound sugars in HCC usually bear a strong positive correlation with increased concentrations of serum ?1-AG, HP and ?1-AT